Italy and Spain's Under 21s sides will also play in the Piedmontese town and there will a women's match between Saluzzo and an Italian All Stars team.
“It will be great to promote rugby league in this part of Italy,” said Italy coach Kelly Rolleston, who will work alongside Cameron Ciraldo and Anthony Minichiello during the Azzurri's World Cup campaign.
“It’s fitting that the match is being played in Saluzzo after the massive effort they have made this year playing a side in the French Championship. We will be looking to improve on our performance last week against Lebanon in Beirut and have made several changes to the team that narrowly lost 6-4 in a bid to give more of our domestic players international experience.”
Lorenzo Luccardi and Davide Spinnato, both capped, have been added to the squad, with Michele Marao, Lucas Bruzzone, Carlo De Carli, Paolo Rodasta and Cristian Mairone all making their debuts.
Spain, who are coached by Englishman Darren Fisher, made it to the final qualifying round for this year's World Cup but were beaten by Ireland.
“It's our first game of the year and an historic moment for us, having the seniors and U21s both playing in matches in Italy together with the women," Fisher said. "It's also a great opportunity for me to reward the standout domestic players with debuts.
The fixture is the first time Spain's Under 21s team have played away from home and coach Andrew Pilkington is keen for more games to satisfy the enthusiasm of his players, some of whom drove six hours from Andalucía to meet the bus for the 14-hour journey to Italy.
“Having our first match away from home is yet another experience for a young group who can grow together," Pilkington said. "On a domestic level, Italy is somewhat of a model for us as we look to follow in their footsteps in terms of development.”
Italy 18-Man Squad
Edoardo Pezzano (Spartans Catania), Carlo De Carli, Giuseppe Pagani, Ismail Byaoui (Lions Brescia), Lorenzo Luccardi (XIII del Ducato), Francesco Di Trapani, Davide Spinnato (XIII Palermo Lovers), Jaume Giorgis, Lucas Bruzzone, Gioele Celerino, Mirco Bergamasco, Cristian Mairone, Paolo Radosta (North West Roosters), Alvise Rigo, Tommaso Nicoli, Fabrizio Ciaurro, Matthew Sands (North East Committee), Michele Marao
Spain 17-Man Squad
Iván Ordaz (Irreductibles), Salvador Fajardo, Miguel Olivares, Sergio Perez (Olimpic Alaquas), Samuel Baeza, Jonathan Infante (RC Ontinyent), Vicente Cubes, Aitor Davila, Carlos Jane, Dani Morales, Aitor Romero, Raul Simo (Tigres Torrent), Remy Bueno (US Plaisance XIII), Andrew Pilkington, Antoni Tolmos (Valencian Warriors) - (Two to be added)
Italy U21 20-Man Squad
Luis Iollo, Giannantonio Visentin, Filippo Papamarenghi, Gabriele Radosta, Brad Calcagno, Alberto Mariani, Gabriele Pataro, Gianluca Azzali, Leonardo Grasso, Yacouba Compaore, Alessandro Viani, Francesco Viani, Alberto Berganton, Giordano Arena, Massimiliano Giannino, Luca Bondioli, Lorenzo Leandro, Fausto Perissinotto, Giorgio Draghi, Sebastiano Sapia
Spain U21 17-Man Squad
Adrián Franco (Boquerones Málaga), Ismael Ferrer, Antonio Pozo, Álvaro Ruiz (Córdoba Fénix), Francisco Luis Perez (Mineros Peñarroya-Pueblonuevo), Juan Ignacio Álvarez, Daniel Marco (CR Muro), Jorge García (Olimpic Alaquas), Ángel Gonzálbez, Borja Ochoa (RC Ontinyent), Daniel Morales, José Manuel Santos, Enrique Toledo (Tigres Torrent), Julien Ferrere, Rubén Olivares (Valencian Warriors), Erick Infante, Manuel Merino (Vikings Albal)
By Brad Walter | @BradWalterSport
Chief Correspondent, RLWC2017